RU58841 (or RU-58841) is a compound that belongs to a group called antiandrogens. RU58841 has been investigated for use as a topical treatment for androgenetic alopecia, acne and hirsutism
Antiandrogens block or lessen the biological effects of testosterone and Dihydrotestosterone (DHT) and they do that by antagonizing the androgen receptor in responsive tissues. In other words they dampen or block the function of testosterone and DHT!
The first antiandrogen was discovered a long time ago in the 1960’s. Antiandrogens are meaningful for people with hormonally responsive diseases. Think of benign prostatic hyperplasia, acne, hirsutism, androgenetic alopecia, prostate cancer, hyper-sexuality and sebborhea. A large variety of antiandrogens have been discovered, but only a limited number of antiandrogens are available for clinical use.
RU58841 weakens the biological effects of testosterone and DHT
So contrary to compounds like dutasteride and finasteride RU58841 doesn’t inhibit the production of DHT but simply interferes with the androgen receptor. Androgen receptors are expressed in many tissues through the body. They are also expressed in the scalp and hair follicle. In fact, the balding hair follicle has shown to express more androgen receptors than non-balding hair follicles (1). Let us look at the normal function of the androgen receptor below and illustrate the relevance of RU58841 towards androgenetic alopecia.
Imagine the elliptical above here being a cell of your hair follicle or your skin. Normally testosterone would enter the cell and if 5a-reductase is present it would convert to DHT. Both of them would then after bind to the androgen receptor. After this, the androgen receptor would shift itself to the nucleus where a couple of other processes occur. What RU58841 does is: RU58841 binds itself to the androgen receptor so that both androgens (DHT + Testosterone) can’t do their job as well as they normally would do.
If you look at all this, it is of no surprise that people who are born with defective androgen receptor in their body don’t have to deal with androgenetic alopecia, since androgens are pretty much useless without functional androgen receptors.
RU58841 has been designed as a topical antiandrogen
RU58841 has been designed as a topical antiandrogen. As you can imagine it would not be wise to block androgen receptor functions throughout the whole body, but rather block the androgen receptor as much locally to the scalp and hair follicle. Since RU58841 has a very short half-life of only 1 hour, it is a perfect candidate for AGA because it works as localized as possible in the scalp or skin. An another nice fact is that the structure of this compound is different than all natural steroids in our body. It’s a non-steroidal anti androgen / chemical structure, and does not interfere with the hormonal level.
For most countries RU58841 has never been officially approved and is only available as a “research chemical” and so can be only purchased by researchers for their research.
RU58841 available as a topical treatment in Indonesia
As mentioned before, most researchers have to order their RU58841 as a research chemical from research companies. As an exception for some reason, RU58841 is available as a topical “FDA approved” treatment in Indonesia. It is sold under the brand name “Mezogenrx” and can be legally purchased from any pharmacy in Indonesia. It is sold in a 1% and 2% RU concentration, combined with Minoxidil and that is combined in just one topical solution. So if you live in Indonesia just go to your local pharmacy and purchase RU58841 as a topical treatment.
RU58841 Solutions and Topicals
Since most of us don’t live in Indonesia, we have to buy pre-mixed RU58841 solutions or mix our own RU58841 solutions for research purpose. Some researchers purchase premixed solutions and some mix their own solutions, often at 5% strength. This video guide explains how to exactly mix RU58841 for research purpose. It also contains a nice FAQ and provides answers to most common issues and mistakes.
- NA Hibberts. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. 1998 Jan;156(1):59-65.